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Amino acid biosynthesis   Aromatic amino acid family Aspartate family Glutamate family Pyruvate family Serine family Histidine family Other Biosynthesis of cofactors, prosthetic groups, and carriers   Biotin Folic acid Heme, porphyrin, and cobalamin Lipoate Menaquinone and ubiquinone Molybdopterin Pantothenate and coenzyme A Pyridoxine Riboflavin, FMN, and FAD Glutathione and analogs Thiamine Pyridine nucleotides Chlorophyll and bacteriochlorphyll Siderophores Other Cell envelope   Surface structures Biosynthesis and degradation of murein sacculus and peptidoglycan Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides Other Cellular processes   Cell division Chemotaxis and motility Cell adhesion Conjugation Detoxification DNA transformation Sporulation and germination Toxin production and resistance Pathogenesis Adaptations to atypical conditions Biosynthesis of natural products Other Central intermediary metabolism   Amino sugars One-carbon metabolism Phosphorus compounds Polyamine biosynthesis Sulfur metabolism Nitrogen fixation Nitrogen metabolism Electron carrier regeneration Other DNA metabolism   DNA replication, recombination, and repair Restriction/modification Degradation of DNA Chromosome-associated proteins Other Disrupted reading frame   Disrupted reading frame Energy metabolism   Aerobic Amino acids and amines Anaerobic ATP-proton motive force interconversion Electron transport Entner-Doudoroff Fermentation Glycolysis/gluconeogenesis Pentose phosphate pathway Pyruvate dehydrogenase Sugars TCA cycle Methanogenesis Biosynthesis and degradation of polysaccharides Photosynthesis Chemoautotrophy Other Fatty acid and phospholipid metabolism   Biosynthesis Degradation Other Hypothetical proteins   Conserved Hypothetical proteins Conserved Domain proteins Hypothetical proteins Mobile and extrachromosomal element functions   Plasmid functions Prophage functions Transposon functions Other Protein fate   Protein and peptide secretion and trafficking Protein modification and repair Protein folding and stabilization Degradation of proteins, peptides, and glycopeptides Other Protein synthesis   tRNA aminoacylation Ribosomal proteins: synthesis and modification tRNA and rRNA base modification Translation factors Other Purines, pyrimidines, nucleosides, and nucleotides   2'-Deoxyribonucleotide metabolism Nucleotide and nucleoside interconversions Purine ribonucleotide biosynthesis Pyrimidine ribonucleotide biosynthesis Salvage of nucleosides and nucleotides Sugar-nucleotide biosynthesis and conversions Other Regulatory functions   DNA interactions RNA interactions Protein interactions Small molecule interactions Other Signal transduction   Two-component systems PTS Other Transcription   Degradation of RNA DNA-dependent RNA polymerase Transcription factors RNA processing Other Transport and binding proteins   Amino acids, peptides and amines Anions Carbohydrates, organic alcohols, and acids Cations and iron carrying compounds Nucleosides, purines and pyrimidines Porins Other Unknown substrate Unclassified   Role category not yet assigned Unknown function   Enzymes of unknown specificity General

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